Kpv 10Mg

KPV (Lysine-Proline-Valine) | Anti-Inflammatory Tripeptide

The “Natural Mast Cell” Modulator

KPV is a potent, non-steroidal tripeptide derived from the C-terminal fragment of alpha-Melanocyte-Stimulating Hormone (\alpha-MSH). Unlike its parent molecule, KPV does not possess melanogenic (tanning) properties, making it a specialized tool for studying systemic and localized inflammation. In research settings, it is highly regarded for its ability to interact directly with the interior of cells to shut down inflammatory signaling at the source.

Potent Cytoprotection: Investigated for its ability to reduce the severity of inflammatory “storms.”
Microbiome-Friendly: Extensively studied in models of inflammatory bowel disease (IBD) for its gut-healing potential.
Antimicrobial Properties: Research suggests it may disrupt the cell walls of certain pathogens, including Candida albicans.

Mechanism of Action

KPV operates through a unique intracellular pathway that distinguishes it from traditional anti-inflammatories:

NF-\kappaB Inhibition: KPV enters the cell and inhibits the translocation of Nuclear Factor-kappa B (NF-\kappaB), the “master switch” for inflammatory gene expression.
Melanocortin Receptor Interaction: While it has a low affinity for most MC receptors, it appears to exert its effects through the MC1R receptor on leukocytes and intestinal epithelial cells.
Mast Cell Stabilization: Research focuses on KPV’s ability to prevent mast cell degranulation, which is critical for studying allergic responses and histamine intolerance.
Transporter Utilization: In gut research, KPV is known to be efficiently taken up by the PepT1 transporter, allowing for high bioavailability in intestinal tissue.

Potential Research Applications

Gastrointestinal Health: Studying the reduction of mucosal inflammation in models of Ulcerative Colitis and Crohn’s Disease.
Dermatological Repair: Investigating the treatment of psoriasis, eczema, and dermatitis without the side effects of corticosteroids.
Wound Healing & Scarring: Researching the prevention of hypertrophic scars by modulating the inflammatory phase of tissue repair.
Allergic & Histamine Research: Exploring the peptide’s role in stabilizing the immune system’s response to environmental triggers.

Technical Specifications

CAS Number: 67909-49-3
Molecular Formula: C_{16}H_{30}N_{4}O_{4}
Sequence: Lys-Pro-Val
Purity: >99\% Research Grade
Appearance: Lyophilized white powder
Disclaimer: Research Use Only

This product is strictly for laboratory research and in vitro studies only. It is not for human or veterinary use. All handling must be performed by qualified professionals in a controlled environment according to local safety regulations.