Cjc-1295 with dac 5Mg

CJC-1295 with DAC | GHRH Analog

The “Sustained Release” Growth Secretagogue

CJC-1295 with DAC (Drug Affinity Complex) is a synthetic 30-amino acid analog of Growth Hormone-Releasing Hormone (GHRH). Unlike the “No DAC” version (Modified GRF 1-29), which requires frequent administration, this variant is engineered with a Lys(Maleimide-\beta-Ala) attachment. This specific modification allows the peptide to bind to serum albumin, creating a long-acting reservoir that significantly extends its half-life to several days.

Extended Bioavailability: Designed to provide a steady elevation of Growth Hormone (GH) levels rather than short-lived pulses.
Superior Stability: Resistant to rapid enzymatic degradation by DPP-4.
GH/IGF-1 Axis Optimization: Frequently used in longitudinal studies to observe the long-term effects of increased IGF-1 on tissue repair and metabolism.

Mechanism of Action

CJC-1295 with DAC functions as a potent GHRH receptor agonist:

Pituitary Stimulation: It binds to GHRH receptors on the anterior pituitary somatotrophs, triggering the synthesis and secretion of endogenous growth hormone.
Bioconjugation (The DAC Effect): The Maleimidopropionyl group forms a covalent bond with circulating albumin. This prevents renal clearance and protects the peptide, allowing for sustained GH release for over 6–8 days after a single administration.
IGF-1 Modulation: By maintaining a baseline elevation of GH, it stimulates the liver to produce a consistent rise in Insulin-like Growth Factor 1 (IGF-1).

Potential Research Applications

Cellular Repair & Regeneration: Investigating the impact of chronic GH elevation on ligament, tendon, and muscle tissue recovery.
Metabolic Efficiency: Researching visceral fat loss and the modulation of lipid metabolism in animal models.
Deep Sleep Architecture: Studying how sustained GHRH agonism influences the quality of slow-wave sleep.
Anti-Aging Research: Exploring the reversal of somatopause—the natural decline of GH levels associated with aging.

Technical Specifications

CAS Number: 446262-90-4
Molecular Formula: C_{165}H_{269}N_{47}O_{46}
Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Malimide-beta-Ala)-NH2
Disclaimer: Research Use Only

This product is strictly for laboratory research and in vitro studies only. It is not for human or veterinary use. All handling must be performed by qualified professionals according to local safety regulations.