Nad+ 500Mg

NAD+ (Nicotinamide Adenine Dinucleotide) | Coenzyme & Redox Catalyst

The “Master Regulator” of Cellular Energy

NAD+ is a fundamental coenzyme found in all living cells, acting as a critical electron carrier in the mitochondrial respiratory chain. In research settings, NAD+ is the focal point for studying metabolic homeostasis, DNA repair, and longevity. As organisms age, systemic NAD+ levels naturally decline, making this molecule the “gold standard” for investigating the reversal of age-related physiological decay.

Universal Bioenergetics: Essential for the conversion of nutrients into Adenosine Triphosphate (ATP).
Sirtuin Activation: Acts as a mandatory co-substrate for SIRT enzymes, which regulate gene expression and aging.
DNA Integrity: Required by PARP enzymes to detect and repair damaged genetic material.

Mechanism of Action

NAD+ operates through two primary biological pathways: Redox Reactions and Cellular Signaling.

Mitochondrial Respiration: It oscillates between its oxidized (NAD^+) and reduced (NADH) forms to facilitate the Electron Transport Chain, fueling the cell’s “powerhouse.”
Enzymatic Consumption: Unlike its role in redox reactions where it is recycled, NAD+ is consumed by Sirtuins and PARPs. These enzymes depend on high NAD+ availability to maintain mitochondrial biogenesis and genomic stability.
Circadian Rhythm Regulation: NAD+ levels fluctuate with the body’s internal clock, providing a research window into sleep-wake cycle optimization and metabolic timing.

Potential Research Applications

Longevity & Senescence: Investigating the “Hallmarks of Aging” and how replenishing NAD+ pools can delay cellular exit from the cell cycle.
Neurodegenerative Studies: Researching the neuroprotective effects of NAD+ in models of cognitive decline and axonal protection.
Exercise Physiology: Studying the enhancement of muscular endurance and the reduction of oxidative stress during high-intensity metabolic demands.
Cardiovascular Health: Exploring the role of NAD+ in maintaining vascular elasticity and endothelial function.

Technical Specifications

CAS Number: 53-84-9
Molecular Formula: C_{21}H_{27}N_{7}O_{14}P_{2}
Purity: >99\% Research Grade
Appearance: Lyophilized white to off-white powder
Disclaimer: Research Use Only

This product is strictly for laboratory research and in vitro studies only. It is not for human or veterinary use. All handling must be performed by qualified professionals in a controlled environment according to local safety regulations.