Pt-141 10Mg

PT-141 (Bremelanotide) | Central Nervous System Agonist

The “Neurogenic” Arousal Catalyst

PT-141 is a first-in-class research peptide that shifts the focus of sexual dysfunction studies from the vascular system to the Central Nervous System (CNS). Unlike traditional phosphodiesterase-5 (PDE5) inhibitors that rely on blood flow, PT-141 is a synthetic cyclic heptapeptide analog of \alpha-melanocyte-stimulating hormone (\alpha-MSH). It targets the brain’s internal signaling pathways to investigate the biological roots of desire and arousal.

CNS-Targeted: Bypasses the cardiovascular system to act directly on melanocortin receptors in the brain.
Rapid Research Onset: Typically exhibits measurable physiological responses within 30 to 60 minutes in laboratory models.
Broad Research Utility: Evaluated for its impact on both male and female sexual behavior pathways.

Mechanism of Action

PT-141 operates as a non-selective Melanocortin Receptor Agonist, with a particularly high affinity for the MC3R and MC4R receptors:

Hypothalamic Activation: Stimulates the paraventricular nucleus (PVN) and the medial preoptic area (mPOA) of the hypothalamus—regions critical for sexual motivation.
Dopaminergic Synergy: Research indicates that MC4R activation triggers the release of dopamine in the mesolimbic reward system, enhancing “solicitational behavior.”
Neurogenic Response: Promotes erectile function and female arousal through neural signals rather than direct vasodilation, making it a unique tool for studying psychogenic dysfunction.

Potential Research Applications

Hypoactive Sexual Desire Disorder (HSDD): Investigating the restoration of sexual motivation and the reduction of associated distress.
Erectile Dysfunction (ED): Studying alternative pathways for subjects who are non-responsive to PDE5 inhibitors like Sildenafil.
Neurobiology of Desire: Mapping the role of the melanocortin system in human and animal “reward-seeking” behaviors.
Energy Homeostasis: Exploring the crossover effects of MC4R stimulation on appetite and metabolism.

Technical Specifications

CAS Number: 189691-06-3
Molecular Formula: C_{50}H_{68}N_{14}O_{10}
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Appearance: Lyophilized white powder
Disclaimer: Research Use Only

This product is strictly for laboratory research and in vitro studies only. It is not for human or veterinary use. All handling must be performed by qualified professionals in a controlled environment according to local safety regulations.