Cagrilintide 5Mg

Cagrilintide | Amylin Receptor Agonist

The “Satiety Signal” Specialist

Cagrilintide represents a novel class of metabolic research tools. As a long-acting analog of the pancreatic hormone amylin, it acts as a non-selective agonist of both Amylin (AMYR) and Calcitonin (CTR) receptors. While GLP-1 agonists focus on insulinotropic pathways, Cagrilintide targets the brain’s homeostatic and hedonic centers to regulate fullness and food reward.

Complementary Mechanism: Acts independently of the GLP-1 pathway for distinct metabolic signaling.
Dual Receptor Agonism: Engages both AMYR and CTR for a multi-layered approach to satiety.
Albumin-Bound Stability: Engineered with a fatty diacid moiety for extended half-life in longitudinal research.

Mechanism of Action

Cagrilintide mimics the co-secreted action of natural amylin to provide a powerful anorectic effect:

Central Satiety Activation: Targets the area postrema and hypothalamus to signal meal termination and reduce cravings.
Gastric Emptying Regulation: Slows the rate of nutrient entry into the small intestine, assisting in the study of postprandial glucose spikes.
Glucagon Suppression: Works to modulate glucagon release, providing a secondary lever for blood glucose research.

Potential Research Applications

Synergistic Co-Administration: Investigating the “additive effect” when paired with GLP-1 agonists (e.g., Semaglutide).
Obesity & Weight Homeostasis: Researching body weight reduction through non-incretin-based pathways.
Type 2 Diabetes (T2D): Exploring glycemic control and HbA1c reduction via improved satiety and slowed digestion.
Food Reward Circuitry: Studying the peptide’s impact on the brain’s hedonic response to high-calorie stimuli.

Technical Specifications

CAS Number: 1415456-99-3
Molecular Formula: C_{194}H_{312}N_{54}O_{59}S_{2}
Disclaimer: Research Use Only

This product is strictly for laboratory research and in vitro studies only. It is not for human or veterinary use. All handling must be performed by qualified professionals in a controlled environment according to local safety regulations.