Tesamorelin 5Mg

Tesamorelin | Selective GHRH Analog

The “Visceral Adipose” Specialist

Tesamorelin is a synthetic 44-amino acid peptide and a potent analog of Growth Hormone-Releasing Hormone (GHRH). It is specifically stabilized with a hexenoyl group at the N-terminal position, making it significantly more resistant to enzymatic degradation than natural GHRH. In research settings, it is the premier tool for studying the targeted reduction of visceral adipose tissue (VAT) and the preservation of metabolic health in immunocompromised models.

Targeted Lipolysis: Renowned for its ability to reduce deep abdominal fat while sparing subcutaneous fat.
Pituitary Precision: Stimulates the natural, pulsatile release of endogenous Growth Hormone.
Metabolic Support: Investigated for its role in improving lipid profiles and insulin sensitivity.

Mechanism of Action

Tesamorelin functions as a highly selective GHRH receptor agonist:

Somatotroph Stimulation: It binds to GHRH receptors in the anterior pituitary, triggering the synthesis and pulsatile secretion of Growth Hormone (GH).
IGF-1 Modulation: The resulting elevation in GH stimulates the liver to produce Insulin-like Growth Factor 1 (IGF-1), which mediates many of the peptide’s growth and repair effects.
Lipolytic Pathway: Specifically targets the breakdown of visceral fat through the activation of hormone-sensitive lipase (HSL) and the inhibition of lipoprotein lipase (LPL) in deep abdominal depots.

Potential Research Applications

Visceral Adiposity Research: Studying the reduction of “hard” belly fat and its impact on systemic inflammation.
Lipodystrophy Models: Investigating the management of abnormal fat distribution in specialized research populations.
Cognitive Health: Emerging research into the neuroprotective effects of GHRH analogs and their impact on mild cognitive impairment.
Growth Hormone Deficiency: Exploring the efficacy of stabilized GHRH analogs versus synthetic GH for maintaining physiological hormone pulses.

Technical Specifications

CAS Number: 218949-48-5
Molecular Formula: C_{221}H_{366}N_{72}O_{67}S
Sequence: trans-3-Hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
Purity: >99\% Research Grade
Disclaimer: Research Use Only

This product is strictly for laboratory research and in vitro studies only. It is not for human or veterinary use. All handling must be performed by qualified professionals in a controlled environment according to local safety regulations.